CVE-2026-17583Thermo Fisher Applied Biosystems Genetic Analyzers Missing Support for Integrity Check
- 8.3HighCVSS base score
- 0.14%Exploitation in 30 daysEPSS · top 97% of all CVEs
- NoKnown exploitednot in CISA's KEV catalog
- NonePublic exploitsnone known yet
Description
The affected Thermo Fisher Applied Biosystems Genetic Analyzers are vulnerable because .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes.
Timeline
ID reserved
By icscert
- 9 days later
· 9 days later
Published
- 1 day later
· 1 day later
Record updated
Changes after publication (a new score, a public exploit, EPSS crossing 1, 10 or 50 %, leaving KEV) are kept since November 2026; earlier ones are not known.
Scores
| Scored by | CVSS | Score | Vector |
|---|---|---|---|
| icscertCNA (assigner) | 4.0 | High8.3 | CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:H/SC:N/SI:H/SA:N |
| icscertCNA (assigner) | 3.1 | High8.4 | CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H |
| NVDNVD · Analyzed | 4.0 | High8.3 | CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:H/SC:N/SI:H/SA:N/E:X/CR:X/IR:X/AR:X/MAV:X/MAC:X/MAT:X/MPR:X/MUI:X/MVC:X/MVI:X/MVA:X/MSC:X/MSI:X/MSA:X/S:X/AU:X/R:X/V:X/RE:X/U:X |
- EPSS (exploitation in 30 days)
- 0.14% · top 97% of all CVEs (13 Nov 2026)
- CISA SSVC
- Exploitation: none · Automatable: no · Technical impact: total
The list uses the assigner's score when there is one, then CISA's, then NVD's: High 8.3.
Affected products
Thermo Fisher · Applied Biosystems 3500/3500xL Series Data Collection Software
- affected ≤ 4.0.2
Thermo Fisher · Applied Biosystems 3730/3730xL Series Data Collection Software
- affected ≤ 5.0.2
Thermo Fisher · Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software
- affected ≤ 1.2.5
Thermo Fisher · Applied Biosystems SeqStudio Flex Series Instrument Software
- affected ≤ 1.2.0
Thermo Fisher · Applied Biosystems GeneMapper ID-X Software
- affected ≤ 1.7.3
Thermo Fisher · Applied Biosystems 3130 Series Data Collection Software
- affected ≤ 4.1
Thermo Fisher · ABI PRISM 3100/3100-Avant Data Collection Software
- affected ≤ 2.0
Thermo Fisher · ABI PRISM 310 Data Collection Software
- affected ≤ 3.1
What to do
Solution: Thermo Fisher has developed security updates to address the vulnerability. The security updates implement the use of digital signatures on the instrument software that adds an extralayer of protection. Moving forward, this will help users verify that data files have not been modified. Applied Biosystems 3500/3500xL Series Data Collection Software: Update to version 4.0.3 https://downloads.thermofisher.com/3500_DCS_v4.0.3_Patch/v4.0.3_Patch_Installer.exe Applied Biosystems 3730/3730xL Series Data Collection Software: Update to version 5.0.3 https://downloads.thermofisher.com/3730xl_UDC_v5.0.3_Patch/3730xl_UDC_v5.0.3_Patch.exe Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software: Update to version 1.2.6 https://downloads.thermofisher.com/SeqStudio/1.2.6/SeqStudio-1.2.6.abpkg Applied Biosystems SeqStudio Flex Series Instrument Software: Update to version 1.2.1 https://downloads.thermofisher.com/SeqStudioFlex/1.2.1/SeqStudioFlex-1.2.1.abpkg Applied Biosystems GeneMapper ID-X Software: Update to version 1.7.4 https://downloads.thermofisher.com/GeneMapperID-Xv1.7.4_Patch/GMIDX_v1.7.4_Patch.exe
Workaround: Applied Biosystems 3130 Series Data Collection Software: Product is End of Life (EoL), no update provided ABI PRISM 3100/3100-Avant Data Collection Software: Product is End of Life (EoL), no update provided ABI PRISM 310 Data Collection Software: Product is End of Life (EoL), no update provided For users who are unable to immediately implement all applicable security updates, Thermo Fisher Scientific recommends implementing the following interim mitigation measures until the applicable updates have been installed: * Maintain a secure chain of custody for files generated by the HID instrumentation throughout the analysis workflow. * Store generated files on encrypted, password-protected storage media (for example, encrypted USB drives or encrypted hard drives). * Restrict access to generated files to authorized personnel in accordance with your laboratory's access control policies. * Apply the principle of least privilege by limiting user permissions on systems operating the HID instrumentation or hosting associated data analysis and secondary analysis software. * Leverage firewall rules and network access control lists (NACLs) to restrict internet connectivity to only trusted sources. For more information, refer to Thermo Fisher's security bulletin. https://documents.thermofisher.com/TFS-Assets/CORP/Product-Guides/fsa_hid_bulletin.pdf
References
Sources
The same CVE in the primary databases and aggregators, to check against.
- CVE.org record (opens in a new tab)
- CVE List JSON (GitHub) (opens in a new tab)
- NVD (opens in a new tab)
- FIRST EPSS (opens in a new tab)
- EUVD EUVD-2026-53616 (opens in a new tab)
- OSV.dev (opens in a new tab)
- GitHub Advisories (opens in a new tab)
- CIRCL Vulnerability-Lookup (opens in a new tab)
Badge for a README or a ticket
[](https://cveledger.app/cve/CVE-2026-17583)Record last updated .